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Microbiology Interview Questions & Answers

Below we have listed all the Microbiology Interview Questions and answers. Feel free to comment on any Microbiology Interview Questions or answer by the comment feature available on the page.

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Microbiology Interview Questions & Answers

Microbiology is the study of organisms, most of which are too small to be seen with the naked eye, including bacteria, algae, protozoa, and fungi, as well as acellular agents, such as viruses and prions. Eukaryotic micro-organisms possess membrane-bound cell organelles and include fungi and protists, whereas prokaryotic organisms—all of which are microorganisms—are conventionally classified as lacking membrane-bound organelles and include eubacteria and archaebacteria. Microbiologists traditionally relied on culture, staining, and microscopy. However, less than 1% of the microorganisms present in common environments can be cultured in isolation using current means. Microbiologists often rely on extraction or detection of nucleic acid, either DNA or RNA sequences.

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All of the following are syndromes associated with enteroviruses EXCEPT?
A. Conjuctivitis
B. Coronary artery disease
C. Myocarditis
D. Pericarditis
E. Pleuritis
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Infections caused by anaerobes are?

* A. Usually confined to the abdomen
B. Never seen in the lung because of its excellent blood supply
C. Mixed
D. Rapidly progressive
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You receive a urine culture report from the laboratory on a 45 year old patient who is a quadriplegic with an indwelling urinary tract catheter. The urine culture is growing >100,000 oxidase positive gram negative bacilli. The most likely organism is?
A. E. coli
B. Enterococcus
C. Klebsiella
D. Pseudomonas aeruginosa
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A 42 year old woman who was complaining of shaking chills and fever went to the Salt Lake City Homeless clinic. She had enlarged lymph nodes in the right axilla. Upstream from the enlarged nodes was an ulcer on the top of the patients right hand. When carefully questioned, the patient said she remembered being bitten there by an insect resembling a horsefly, but with yellow stripes on its abdomen; Its what we used to call a deerfly, she added laconically. The patient denied any contact with rats or fleas. The patients disease was most likely to be:?
A. Brucellosis
B. Ulcero-glandular tularemia
C. Pneumonic plague
D. Relapsing fever
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A 20 year old college student is part of an archeological team traveling to northeastern Arizona to help excavate Indian ruins. One month after returning she develops a flu-like illness with cough, myalgias, and low grade fever. A chest x-ray shows a small localized infiltrate in the right mid lung field. An organism to consider would be?
A. Histoplasma
B. Coccidioides
C. Legionella
D. Brucella
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One of the key differences between amantidine/rimantidine and the newer neuraminidase inhibitor influenza virus drugs is?
A. drug allergy
B. antimetabolic effect on host cells due to lack of specificity for viral enzymes
C. rate of development of drug resistance
D. drug-drug interactions associated with competition for cytochrome P450 enzymes
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Influenza virus hemagglutinins play a significant role in which of the following phases of viral replication?
A. Uncoating
B. Virion Assembly
C. Release by budding
D. Adsorption
E. Production of mRNA
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A 20 year old patient comes to the homeless clinic with a skin abscess on the right arm. A swab from the intact skin overlying this abscess grows coagulase negative staphylococci. An aspirate obtained sterilely with a needle and syringe grows Staphylococcus aureus. About these 2 organisms in this patient you can say?
A. Both are normal flora and contaminated the specimens sent to the lab
B. The staph aureus is a pathogen and the coagulase negative staph is not
C. The coagulase negative staphylococcus is a pathogen
D. The coagulase negative staphylococcus is an opportunistic pathogen
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The lesions of bacillary angiomatosis in AIDS patients are very similar to the hemangiomatous nodules caused by?
A. Rickettsia prowazekii
B. Ehrlichia chaffeensis
C. Bartonella bacilliformis
D. Coxiella burnetii
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It is extremely difficult to eradicate staphylococcal infection in the presence of a foreign body. Thus, infected artificial joints and infected intravenous lines often must be removed in conjunction with optimal intravenous anti-staphylococcal therapy with oxacillin or nafcillin (sometimes in combination with rifampin) in order to eradicate such staphylococcal infections (and these attempts are not always successful). Staphylococcal infection of bone may persist for many years despite what should be optimal antimicrobial therapy. The most likely reason for this tenacity of staphylococcal osteomyelitis is:?
A. The Staphylococcal pilus gene is up-regulated by oxacillin
B. Fragments of dead bone, called "involucrum" may act as a foreign body, and may have to be removed for optimal eradication of the staphylococcal infection.
C. Staphylococci may be perceived by the patient's immune system as a positive factor, because the staphylococci produce an extracellular enzyme, obtundokinase, which makes the patient more alert.
D. Staphylococci are such an integral part of our normal flora that they are treated as "self" rather than "non-self", and no immune reaction to them occurs.
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A Chinese male has had right upper quadrant pain for the past 10 years. Workup for gallbladder disease with an ultrasound shows small linear organisms. O&P exam reveals the ovoid, flask shaped egg of Clonorchis sinensis. Which of the following statements is false regarding Clonorchis sinensis?
A. It is also called the oriental liver fluke
B. Man is a definitive host
C. This infection can best be treated with surgical removal of the gallbladder
D. There are two intermediate hosts - the snail and the fish
E. Long-term infection has been associated with cholangiocarcinoma (cancer of the bile duct)
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The diagnosis of septicemia should be considered in patients who are at increased risk of blood stream infection (often secondary to local disease, such as urinary tract infection or pneumonia). All of the following are factors predisposing patients to septicemia except?
A. Underlying diseases that appear to compromise host defenses, such as diabetes, lymphoma, etc
B. Patients with a polymorphonuclear leukocyte count less than 1000/mm3
C. Patients with polymorphonuclear leukocyte counts of 10,000 to 20,000
D. Long term therapy with broad-spectrum antimicrobials.
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A major characteristic of hepatitis C is?
A. It is transmitted by eating raw oysters
B. It is highly likely to cause chronic ongoing infection
C. Most patients have severe symptoms when first infected
D. It is a DNA virus
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Legionella infection is more common in patients who?
A. Are smokers with COPD
B. Are diabetics
C. Are premature infants
D. Are patients on broad spectrum antibiotics?
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Which of the following extracellular enzymes produced by Group A-streptococci is called “spreading factor”, an enzyme important in skin and soft tissue infection?
A. Streptokinase
B. Hyaluronidase
C. M Protein
D. Deoxyribonuclease C
E. None of the above
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Each of the following statements concerning epidemic typhus is correct EXCEPT?
A. The disease is characterized by a rash that begins on the trunk and moves distally.
B. The recrudescent form of the disease is called Brill-Zinsser
C. The disease is caused by Rickettsia typhi
D. The causative organism is transmitted to humans by lice
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Several years ago there was an outbreak of Trichinosis among a group of Vietnam immigrants in New York that had made their own pork sausage. About 30 people who ate the sausage all become ill. Which of the following statements is false about Trichinella spiralis?
A. It can be spread by eggs passed in the stool
B. It is a tissue nematode that induces a high eosinophil response
C. It is a disease of meat eating animals
D. It is usually self limiting
E. Heavy infection causes symptoms of diarrhea and abdominal pain that progresses to fever, facial and periorbital edema and myalgias
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A 30 year old patient with advanced HIV infection comes into clinic complaining that food is sticking in the back of his throat and in his chest when he tries to swallow. You look in his mouth and see patches of whitish material on the surface that can easily be removed and leaves a red base. The organism most likely to cause this is?
A. Histoplasma
B. Candida albicans
C. Group A- strep
D. Strongyloides
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Specific organisms that are considered strict anaerobes include?
A. E. coli and Streptococcus pneumoniae
B. Bacteroides and Klebsiella
C. Fusobacterium and Clostridium
D. Peptostreptococcus and Nocardia
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An elderly Tongan male was diagnosed with multiple myeloma (a form of cancer) and has been treated with chemotherapy agents for two months. He was then admitted to the hospital with new-onset asthma symptoms that became worse when he was treated with steroids. Many small larvae were found in his sputum and he was found to have a hyper-infection with Strongyloides stercoralis. Which statement is false regarding Strongyloides?
A. Strongyloides is a common cause of iron deficiency anemia just like hookworm
B. The initial infection occurs when larvae penetrate the skin from the soil
C. Auto infection occurs when the ova hatch and mature in the intestinal tract and then penetrate the intestine to establish a persistent infection
D. Eosinophilia is present during the migrating phase of the life cycle
E. Recurrent bacterial infections can develop when bacteria are carried by the larvae into sterile areas of the body
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Latest 20 Questions
Payment of time- barred debt is: (a) Valid (b) Void (c) Illegal (d) Voidable
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