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INTERVIEW QUESTIONS MBBS PHARMACOLOGY DETAILS

Question: Hypnotic benzodiazepines can cause:

A dose-dependent increase in both REM and slow wave sleep
Do not change sleep patterns
A dose-dependent decrease in both REM and slow wave sleep
A dose-dependent increase in REM sleep and decrease in slow wave sleep

Answer: A dose-dependent decrease in both REM and slow wave sleep

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Question: Hypnotic benzodiazepines can cause:

A dose-dependent increase in both REM and slow wave sleep
Do not change sleep patterns
A dose-dependent decrease in both REM and slow wave sleep
A dose-dependent increase in REM sleep and decrease in slow wave sleep


Answer:

A dose-dependent decrease in both REM and slow wave sleep Source: CoolInterview.com



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Related Questions
View Answer
Which one of the following hypnotic benzodiazepines is more likely to cause rebound insomnia?

Triazolam
Flurazepam
Temazepam
All of the above
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Which of the following hypnotic benzodiazepines is more likely to cause “hangover” effects such as drowsiness,
dysphoria, and mental or motor depression the following day?

Temazepam
Triazolam
Flurazepam
None of the above
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Indicate the hypnotic drug, which binds selectively to the BZ1 receptor subtype, facilitating GABAergic inhibition:

Thiopental
Zolpidem
Flurazepam
Phenobarbital
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Which of the following statements is correct for zolpidem?

Causes minor effects on sleep patterns
The risk of development of tolerance and dependence is less than with the use of hypnotic benzodiazepines
Has minimal muscle relaxing and anticonvulsant effects
All of the above
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Which agent exerts hypnotic activity with minimal muscle relaxing and anticonvulsant effects?

Flurazepam
Triazolam
Zaleplon
None of the above
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2-iminothiazolidine is treated with phenyloxirane to get a drug used in roundworm infection is

piperazine
tetramisole
thiabendazole
levamisole
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A new drug delivery system which is composed of phospholipids that spontaneously form a multilamellar concentric bilayer vesicles with layers of aqueous media separating the lipid layers is

prodrugs
liposomes
osmotic pumps
nanoparticles
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Unless otherwise stated in the individual monograph of the pharmacopoeia, in the disintegration test for enteric coated tablets, first the dissolution is carried out in

0.1 M HCl
phosphate buffer
water
0.1 M HSO 2 4
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What is the proportion of NaCl required to render a 1.5% solution of drug isotonic with blood plasma? The freezing point of 1% w/v solution of drug is -0.122°C and that of NaCl is -0.576°C

0.65%
0.585%
0.9%
0.5%
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The mechanism of antiparasitic action of Mebendazole and thiabendazole involves

stimulation of acetylcholine receptors at neuromuscular junctions
inhibition of dihydropolate reductase
interference with microtubule synthesis and assembly
block thiamine transport
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Isoniazid is a primary antitubercular agent that

requires pyridoxine supplementation
causes ocular complications that are reversible if the drug is discontinued
is ototoxic and nephrotoxic
should never be used due to hepatotoxic potential
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Decreased risk of Atherosclerosis is associated with increase in

very low density lipoproteins
low density lipoproteins
cholesterol
high density lipoproteins
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The mechanism of action of Paclitaxel is

bind to DNA through intercalation between specific bases and block the synthesis of new RNA or DNA, cause DNA strand scission
mitotic spindle poison through the enhancement of tubulin polymerization
competitive partial agonist ś inhibitor of estrogen and binds to estrogen receptors
S-Phase specific antimetabolite that is converted by deoxykinase to the 5‘-mononuleotid
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A drug which has antipyretic, anti-inflammatroy and antiplatelet activity is

Sulfinpyrazone
Aspirin
Ticlopidine
Acetaminophen
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A 60 year old patient presents with glaucoma. Therapy should include



Choose the correct combination,
(P) topical atropine
(Q) topical pilocarpine
(R) oral acetazolamide
(S) oral pilocarpine

P, Q
Q, R
R, S
P, S
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Bioassays are carried out to

Measure the pharmacological activity of a drug
Avoid clinical trails for new drugs
Detect the impurity in a given drug
Screen fro pharmacognetic influences of new drugs
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A direct way of studying idiosyncratic reactions to a given drug is by

changing the route of drug administration
changing the assay method
pharmacogenomics
structure activity relationship studies of a family of compounds
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An example of haemopoietic growth factor is

platelet derived growth factor
epidermal growth factor
iron dextran
erythropoietin
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It activates IL-2 transcription
Nephrotoxicity is a common adverse effect
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Which of the following ACE inhibitor has highest bioavailability

Captopril
Enalapril
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Payment of time- barred debt is: (a) Valid (b) Void (c) Illegal (d) Voidable
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