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Which one of the following hypnotic benzodiazepines is more likely to cause rebound insomnia?
Triazolam Flurazepam Temazepam All of the above
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Which of the following hypnotic benzodiazepines is more likely to cause “hangover” effects such as drowsiness, dysphoria, and mental or motor depression the following day?
Temazepam Triazolam Flurazepam None of the above
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Indicate the hypnotic drug, which binds selectively to the BZ1 receptor subtype, facilitating GABAergic inhibition:
Thiopental Zolpidem Flurazepam Phenobarbital
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Which of the following statements is correct for zolpidem?
Causes minor effects on sleep patterns The risk of development of tolerance and dependence is less than with the use of hypnotic benzodiazepines Has minimal muscle relaxing and anticonvulsant effects All of the above
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Which agent exerts hypnotic activity with minimal muscle relaxing and anticonvulsant effects?
Flurazepam Triazolam Zaleplon None of the above
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2-iminothiazolidine is treated with phenyloxirane to get a drug used in roundworm infection is
piperazine tetramisole thiabendazole levamisole
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A new drug delivery system which is composed of phospholipids that spontaneously form a multilamellar concentric bilayer vesicles with layers of aqueous media separating the lipid layers is
prodrugs liposomes osmotic pumps nanoparticles
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Unless otherwise stated in the individual monograph of the pharmacopoeia, in the disintegration test for enteric coated tablets, first the dissolution is carried out in
0.1 M HCl phosphate buffer water 0.1 M HSO 2 4
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What is the proportion of NaCl required to render a 1.5% solution of drug isotonic with blood plasma? The freezing point of 1% w/v solution of drug is -0.122°C and that of NaCl is -0.576°C
0.65% 0.585% 0.9% 0.5%
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The mechanism of antiparasitic action of Mebendazole and thiabendazole involves
stimulation of acetylcholine receptors at neuromuscular junctions inhibition of dihydropolate reductase interference with microtubule synthesis and assembly block thiamine transport
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Isoniazid is a primary antitubercular agent that
requires pyridoxine supplementation causes ocular complications that are reversible if the drug is discontinued is ototoxic and nephrotoxic should never be used due to hepatotoxic potential
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Decreased risk of Atherosclerosis is associated with increase in
very low density lipoproteins low density lipoproteins cholesterol high density lipoproteins
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The mechanism of action of Paclitaxel is
bind to DNA through intercalation between specific bases and block the synthesis of new RNA or DNA, cause DNA strand scission mitotic spindle poison through the enhancement of tubulin polymerization competitive partial agonist ś inhibitor of estrogen and binds to estrogen receptors S-Phase specific antimetabolite that is converted by deoxykinase to the 5‘-mononuleotid
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A drug which has antipyretic, anti-inflammatroy and antiplatelet activity is
Sulfinpyrazone Aspirin Ticlopidine Acetaminophen
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A 60 year old patient presents with glaucoma. Therapy should include
Choose the correct combination, (P) topical atropine (Q) topical pilocarpine (R) oral acetazolamide (S) oral pilocarpine
P, Q Q, R R, S P, S
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Bioassays are carried out to
Measure the pharmacological activity of a drug Avoid clinical trails for new drugs Detect the impurity in a given drug Screen fro pharmacognetic influences of new drugs
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A direct way of studying idiosyncratic reactions to a given drug is by
changing the route of drug administration changing the assay method pharmacogenomics structure activity relationship studies of a family of compounds
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An example of haemopoietic growth factor is
platelet derived growth factor epidermal growth factor iron dextran erythropoietin
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Not true about tacrolimus is all except
It binds to cyclophillin It is a prodrug It activates IL-2 transcription Nephrotoxicity is a common adverse effect
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Which of the following ACE inhibitor has highest bioavailability
Captopril Enalapril Fosinopril Ramipril
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