You should always answer yes and briefly explain why. A good explanation is that you have set goals, and you have met some and are on track to achieve the others.
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Can you describe for me a difficult obstacle you have had to overcome? How did you handle it? How do you feel this experience affected your personality or ability?
What do you think are the most important characteristics & abilities a person must possess to become a successful ( )? How do you rate yourself in these areas?