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Question: Barbiturates increase the rate of metabolism of:

Anticoagulants
Digitalis compounds
Glucocorticoids
All of the above

Answer: All of the above



Category Pharmacology Interview Questions & Answers - Exam Mode / Learning Mode
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Question: Barbiturates increase the rate of metabolism of:

Anticoagulants
Digitalis compounds
Glucocorticoids
All of the above

Answer:

All of the above Source: CoolInterview.com



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Which of the following factors can influence the biodisposition of hypnotic agents?

Alterations in the hepatic function resulting from a disease
Old age
Drug-induced increases or decreases in microsomal enzyme activities
All of the above
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Which of the following hypnotics is preferred for elderly patients?

Phenobarbital
Flurozepam
Temazepam
Secobarbital
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Which of the following hypnotics is preferred in patients with limited hepatic function?

Zolpidem
Amobarbital
Flurozepam
Pentobarbital
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Indicate the mechanism of barbiturate action (at hypnotic doses):

Increasing the duration of the GABA-gated Cl- channel openings
Directly activating the chloride channels
Increasing the frequency of Cl- channel opening events
All of the above
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Imidazopyridines are a kind of :

Partial agonists at brain 5-TH1A receptors
Selective agonists of the BZ1 (omega1) subtype of BZ receptors
Competitive antagonists of BZ receptors
Nonselective agonists of both BZ1 and BZ2 receptor subtypes
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Which of the following hypnotic agents is a positive allosteric modulator of GABAA receptor function?

Zaleplon
Flurazepam
Zolpidem
All of the above
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Indicate a hypnotic drug - a selective agonist at the BZ1 receptor subtype:

Flurazepam
Zolpidem
Triazolam
Flumazenil
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Which of the following hypnotic agents is able to interact with both BZ1 and BZ2 receptor subtypes?

Zaleplon
Phenobarbital
Flurazepam
Zolpidem
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Which is the competitive antagonist of BZ receptors:

Flumazenil
Picrotoxin
Zolpidem
Temazepam
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Flumazenil blocks the actions of:

Phenobarbital
Morphine
Zolpidem
Ethanol
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Indicate the agent, which interferes with GABA binding:

Flurazepam
Bicuculline
Thiopental
Zolpidem
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Which of the following agents blocks the chloride channel directly?

Secobarbital
Flumazenil
Zaleplon
Picrotoxin
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Which of the following agents is preferred in the treatment of insomnia?

Barbiturates
Hypnotic benzodiazepines
Ethanol
Phenothiazide
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Barbiturates are being replaced by hypnotic benzodiazepines because of:

Low therapeutic index
Suppression in REM sleep
High potential of physical dependence and abuse
All of the above
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Which of the following benzodiazepines is used mainly for hypnosis?

Clonozepam
Lorazepam
Flurazepam
Midazolam
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Indicate the main claim for an ideal hypnotic agent:

Rapid onset and sufficient duration of action
Minor effects on sleep patterns
Minimal ?hangover? effects
All of the above
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Which stage of sleep is responsible for the incidence of dreams?

REM sleep
Slow wave sleep
Stage 2NREM sleep
All of the above
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During slow wave sleep (stage 3 and 4 NREM sleep):

Dreams occur
The secretion of adrenal steroids is at its highest
Somnambulism and nightmares occur
The secretion of somatotropin is at its lowest
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All of the hypnotic drugs induce:

Increase the duration of REM sleep
Decrease the duration of REM sleep
Do not alter the duration of REM sleep
Increase the duration of slow wave sleep
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Which of the following hypnotic drugs causes least suppression of REM sleep?

Flumazenil
Phenobarbital
Flurazepam
Secobarbital
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